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电话/传真:

+86-10-64807351                                                 

电子邮件:

caiz@im.ac.cn

个人简介:                       

博士,副研究员。主要从事合成生物学研究,包括人工固碳、酶分子改造、生物催化等。

教育背景:

2004.9-2009.7  清华大学化学工程系,直博,生物化工,博士学位

2000.9-2004.7  清华大学化学工程系,本科,化学工程与工艺,学士学位

承担的主要科研项目

中国科学院重点部署项目子课题“新羧化酶的设计、表征与评价”(2016.1-2018.12

863子课题“谷氨酸到戊二酸的生物转化”(2014.1-2016.12

863子课题“戊糖/己糖共利用菌株的选育及高温乙醇发酵技术”(2012.1-2015.12

国家自然科学基金青年基金“核酮糖-1,5-二磷酸羧化/加氧酶的分子改造”(2012.1-2014. 12

5年主要论文

1.         Fuyu Gong, Guoxia Liu, Xiaoyun Zhai, Jie Zhou, Zhen Cai*, Yin Li*, Quantitative analysis of an engineered CO2-fixing Escherichia coli reveals great potential of heterotrophic CO2 fixation, Biotechnology for Biofuels, 2015, 8: 86.

2.         Linjiang Zhu, Yin Li, Zhen Cai*, Development of a stress-induced mutagenesis module for autonomous adaptive evolution of Escherichia coli to improve its stress tolerance , Biotechnology for Biofuels, 2015, 8: 93

3.         Guodong Luan, Zhen Cai*, Yin Li*, Yanhe Ma, Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production, Biotechnology for Biofuels, 2013, 6: 137.

4.         Xinghua Li, Zhen Cai*, Yin Li, Yanping Zhang*, Design and construction of a non-natural malate to 1,2,4-butanetriol pathway creates possibility to rroduce 1,2,4-butanetriol from glucose, Scientific Reports, 2014, 4, 5541.

5.        Guodong Luan, Zhen Cai*, Yin Li*, Yanhe Ma, Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production, Biotechnology for Biofuels, 2013, 6: 137.

6.        Xinghua Li, Zhen Cai*, Yin Li, Yanping Zhang*, Design and construction of a non-natural malate to 1,2,4-butanetriol pathway creates possibility to rroduce 1,2,4-butanetriol from glucose, Scientific Reports, 2014, 4, 5541.

7.         Guodong Luan, Hongjun Dong, Tianrui Zhang, Zhao Lin, Yanping Zhang, Yin Li, Zhen Cai*, Engineering cellular robustness of microbes by introducing the GroESL chaperonins from extremophilic bacteria, Journal of Biotechnology, 2014, 178: 38–40

8.         Linjiang Zhu#, Zhen Cai#, Yanping Zhang and Yin Li*, Engineering stress tolerance of Escherichia coli by stress-induced-mutagenesis (SIM)-based adaptive evolution, Biotechnology Journal, 2014, 9: 1-8.

9.         Zhen Cai, Bo Zhang and Yin Li*, Engineering Saccharomyces cerevisiae for efficient anaerobic xylose fermentation: reflections and perspectives, Biotechnology Journal, 2012, 7: 34-46.