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  毕玉海  博士 副研究员   

                               电话:010-64806013    E-mailbeeyh@im.ac.cn

        中国科学院流感研究与预警中心、中国科学院微生物研究所病原微生物与免疫学重点实验室,流感病毒技术平台负责人。主要从事流感等新发突发人兽共患传染病的遗传进化与预警、跨种间传播及致病机理的研究,在病原监测发现、感染模型、致病机制研究的基础上研发特异性药物和疫苗。发表SCI论文60余篇,第一或通讯作者在Cell Host MicrobeCell ResearchLancetThe Lancet Infectious DiseasesJournal of VirologyTrends in MicrobiologyEmerging Infectious DiseasesJournal of Medicinal ChemistryJournal of Clinical Microbiology等杂志发表27篇研究论文(累积影响因子202.68);申请获授权专利10项。

教育经历

2000-2004,吉林农业大学,生物技术专业,学士

2004-2007,吉林大学,预防兽医学专业,硕士

2007-2010,中国农业大学,预防兽医学专业,博士

在研课题:

1.        国家科技重大专项《艾滋病和病毒性肝炎等重大传染病防治-非洲重要传染病流行规律研究》课题负责人;2016~2020

2.        中国科学院重点部署项目《中国科学院流感研究与预警中心建设及前沿研究》,病毒溯源及遗传进化研究课题负责人;2015~2017

3.        内蒙古鄂尔多斯市乌审旗资助专项基金,《乌审旗禽流感监测》,项目负责人;2015~2017

4.        中国科学院新发和烈性传染病病原学与生物安全重点实验室开放研究基金,《H7N9病毒NA茎部缺失的生物学功能研究》,项目负责人2015.1-2016.12

代表性论文:

1.        Yuhai Bi#, Quanjiao Chen#, Qianli Wang#, Jianjun Chen#, Tao Jin, Gary Wong, Chuansong Quan, Jun Liu, Jun Wu, Renfu Yin, Lihua Zhao, Mingxin Li, Zhuang Ding, Rongrong Zou, Wen Xu, Hong Li, Huijun Wang, Kegong Tian, Guanghua Fu, Yu Huang, Alexander Shestopalov, Shoujun Li, Bing Xu, Hongjie Yu, Tingrong Luo, Lin Lu, Xun Xu, Yang Luo, Yingxia Liu*, Weifeng Shi*, Di Liu* and George Fu Gao*. Genesis, evolution and prevalence of H5N6 avian influenza viruses in China.  Cell Host Microbe. 2016, http://dx.doi.org/10.1016/j.chom.2016.10.022.

2.        Yuhai Bi*#, Haixia Xiao#, Quanjiao Chen#, Yan Wu, Lifeng Fu, Chuansong Quan, Gary Wong, Jun Liu, Joel Haywood, Yingxia Liu, Boping Zhou, Jinghua Yan, Wenjun Liu, George F Gao*. Changes in the length of the neuraminidase stalk region impacts H7N9 virulence in mice. Journal of Virology. 2016 February, 90(4):2142-2149.

3.        Yuhai Bi, Qing Xie, Shuang Zhang, Yun Li, Haixia Xiao, Tao Jin, Weinan Zheng, Jing Li, Xiaojuan Jia, Lei Sun, Jinhua Liu, Chuan Qin, George F. Gao* and Wenjun Liu*. Assessment of the Internal Genes of Influenza A (H7N9) Virus Contributing to High Pathogenicity in Mice. Journal of Virology. 2015 Jan 1; 89(1):2-13.

4.        Shuo Su, Yuhai Bi*#, Gary Wongb, Gregory C. Graye, George F. Gaob, Shoujun Li*. Epidemiology, evolution and recent outbreaks of avian influenza viruses in China. Journal of Virology. 2015 Sep; 89(17):8671-6.

5.        Jing Li, Can Chen, Gary Wong, Wei Dong, Weinan Zheng, Yun Li, Lei Sun, Lianfeng Zhang, George F. Gao, Yuhai Bi* and Wenjun Liu*. Cyclophilin A protects mice against infection by influenza A virus. Scientific Reports. 2016; 6: 28978.

6.        Yan Wu#, Yuhai Bi#, Christopher J Vavricka#, Xiaoman Sun, Yanfang Zhang, Feng Gao, Min Zhao,Haixia Xiao, Chengfeng Qin, Jianhua He, Wenjun Liu, Jinghua Yan, Jianxun Qi, George F Gao*. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research. 2013 Dec;23(12):1347-55.

7.        Lifeng Fu #, Yuhai Bi #, Yan Wu #, Shanshan Zhang, Jianxun Qi, Yan Li, Xuancheng Lu, Zhenning Zhang, Xun Lv, Jinghua Yan, George F. Gao*, and Xuebing Li*. Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses. Journal of Medicinal Chemistry. 2016 Jul 14;59(13):6303-12.

8.        Yuhai Bi*#, Zhenjie Zhang, Wenjun Liu, Yanbo Yin, Jianmin Hong, Xiangdong Li, Haiming Wang, Gary Wong, Jianjun Chen, Yunfeng Li, Wendong Ru, Ruyi Gao, Di Liu, Yingxia Liu, Boping Zhou, George F. Gao, Weifeng Shi*, Fumin Lei*. Highly pathogenic avian influenza A(H5N1) virus struck migratory birds in Chinain 2015. Scientific Reports. 2015 Aug 11, 5:12986.

9.        Tao Zhang#, Yuhai Bi#, Huaiyu Tian#, Xiaowen Li#, Di LiuYing WuTao JinYong WangQuanjiao ChenZe Chen, Jianyu ChangGeorge F. Gao, and Bing Xu*. Human Infection with Influenza Virus A (H10N8) from Live Poultry Markets, China, 2014. Emerging Infectious Diseases. 2014 Dec;20(12):2076-9.

10.    Yuhai Bi#*, Jianjun Chen#, Zhenjie Zhang, Mingxin Li, Tianlong Cai, Kirill Sharshov, Ivan Susloparov, Alexander Shestopalov, Gary Wong, Yubang He, Zhi Xing, Jianqing Sun, Di Liu, Yingxia Liu, Lei Liu, Wenjun Liu, Fumin Lei, Weifeng Shi*, George F. Gao. Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015. Virological Sinica. 2016 Aug;31(4):300-5.

11.    Shuo Su, Gary Wong, Yingxia Liu, George F Gao, Shoujun Li*, Yuhai Bi*. MERS in South Korea and China: a potential outbreak threat? Lancet. 2015 Jun 13;385(9985):2349-50.

12.    Shuo Su#*, Gary Wong#, Weifeng Shi, Jun Liu, Alexander C.K. Lai, Jiyong Zhou, Wenjun Liu, Yuhai Bi* and George F.Gao*. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends Microbiol. 2016 Jun;24(6):490-502.

13.    Gary Wong, Wenjun Liu, Yingxia Liu, Boping Zhou, Yuhai Bi* and George F. Gao*. MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease. Cell Host Microbe. 2015, Oct 14;18(4):398-401.

14.    Shuo Su, Gary Wong, Xiangguo Qiu, Gary Kobinger, Yuhai Bi*, Jiyong Zhou*. Diagnostic strategies for Ebola virus detection. The Lancet Infectious Diseases. 2016. March. Vol. 16, No. 3, p294–295.