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吴燕

电话:010-64807569

E-mailwuyan@im.ac.cn

个人简介:

硕士,助理研究员。主要从事流感病毒神经氨酸酶抑制剂的分子机制、耐药机制及免疫分子结构研究。近年来在Cell Research, PLoS Pathogens, The Journal of Immunology, Journal of Virology等杂志发表文章13篇,其中第一作者(含共享第一作者)文章4篇。

教育经历

2000.9-2004.7  首都师范大学,生物技术,理学学士

2011.9-2013.11  中国科学院大学,生物化学与分子生物学,理学硕士

2014.9-  中国科学院大学,生物化学与分子生物学,在读博士

工作经历

2005.4-2006  中国科学院微生物研究所,项目聘用,助理工程师

2006-2010.6  中国科学院微生物研究所,实习研究员

2010.7-    中国科学院微生物研究所,助理研究员

承担的主要科研项目:

国家自然科学基金青年基金“甲型流感病毒N2亚型神经氨酸酶耐药机制研究”(2014.1-2016.12

已发表论文

1.         Yan Wu#, Yuhai Bi#, Christopher J Vavricka#, Xiaoman Sun, Yanfang Zhang, Feng Gao, Min Zhao, Haixia Xiao, Chengfeng Qin, Jianhua He, Wenjun Liu, Jinghua Yan, Jianxun Qi, George F Gao*. 2013. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research, 23(12):1347-1355.

2.         Yan Wu#, Guangrong Qin#, Feng Gao, Yue Liu, Christopher J. Vavricka, Jianxun Qi, Hualiang Jiang, Kunqian Yu, George F. Gao*. 2013, Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding. Scientific Reports, 3: 1551-1558. 

3.         Christopher J. Vavricka#, Qing Li#, Yan Wu#, Jianxun Qi, Mingyang Wang, Yue Liu, Feng Gao, Jun Liu, Enguang Feng, Jianhua He, Jinfang Wang, Hong Liu, Hualiang Jiang, George F. Gao*. 2011. Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group pecific Mechanisms for Influenza NA Inhibition. PLoS Pathogens, 7: e1002249. #共享第一作者)

4.         Yan Wu, Feng Gao, Jun Liu, Jianxun Qi, Emma Gostick, David A. Price, George F.Gao*. 2011. Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insight into immune protection from SIV. The Journal of Immunology, 187:6382-6392. (With front cover)

5.         Mingyang Wang, Jianxun Qi, Yue Liu, Christopher J. Vavricka, Yan Wu, Qing Li, George F. Gao*, 2011, Influenza A virus neuraminidase N5 has an extended 150-cavity.Journal of Virology, 85 (16): 8431-8435.

6.         Christopher J. Vavricka, Yue Liu, Qing Li, Yi Shi, Yan Wu, Yeping Sun, Jianxun Qi, George F. Gao*, 2011, Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase. (invited review) Chinese Science Bulletin, 56 (17): 1747-11752. (With front cover)

7.         Christopher J. Vavricka, Yue Liu, Hiromasa Kiyota, Nongluk Sriwilaijaroen, Jianxun Qi, Kosuke Tanaka, Yan Wu, Qing Li, Yan Li, Jinghua Yan, Yasuo Suzuki & George F. Gao*, 2012, Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. Nature Communications, 4: 1491.

8.         Yu Zhang, Yulin Ren, Yan Wu, Bao Zhao, Lipeng Qiu, Xiaodong Li, Dongping Xu, Jun Liu, George F. Gao*, Songdong Meng*, 2013, The L60V variation in HBV core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication. Journal of Virology, 87 (14): 8075-8084.

9.         Qing Li, Jianxun Qi, Yan Wu, Hiromasa Kiyota, Kosuke Tanaka, Yoshitomo Suhara, Hiroshi Ohrui, Yasuo Suzuki, Chrisopher Vavricka, George Fu Gao*, 2013, Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir Resistance. Journal of Virology, 87 (18): 10016-10024.

10.     Ying Wu, Yan Wu, Boris Tefsen, Yi Shi, George Fu Gao*, 2014, Bat-derived influenza-like viruses H17N10 and H18N11. Trends in Microbiology, 22 (4): 183-191.

11.     Xiaoman Sun, Qing Li, Yan Wu, Mingyang Wang, Yue Liu, Jianxun Qi, Chrisopher Vavricka, George Fu Gao*, 2014, Comprehensive structural analysis of influenza virus N7 and N6: the last two pieces of the neuraminidase puzzle. Journal of Virology, 88 (16):9197-9207. (With front cover)

12.     Jun Liu, Haixia Xiao, Yan Wu, Di Liu, Xiaopeng Qi, Yi Shi, George Fu Gao*, 2014, H7N9: a low pathogenic avian influenza A virus infecting humans. Current Opinion in Virology, 5: 91-97.

13.     Ying Wu, Christopher J. Vavricka, Yan Wu, Qing Li, Santosh Rudrawar, Robin J. Thomson, Mark von Itzstein, George Fu Gao, Jianxun Qi*, 2015, Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor. Protein & Cell.