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王为善  博士  副研究员

Tel010-64807800

Emailwangws@im.ac.cn

 

教育经历:

2002-2006,山东农业大学,生物技术,理学学士;

2006-2009,中国海洋大学,生物制药,医学硕士;

2009-2013,中国科学院微生物研究所,生物化学与分子生物学,理学博士;

 

工作经历:

2013- 中国科学院微生物所助理研究员(杨克迁课题组);

 

主要研究领域:

链霉菌系统调控网络;

链霉菌代谢转变机制;

链霉菌合成生物学与抗生素代谢工程。

 

代表性论文(# 并列第一作者;*通讯作者):

1.        Wang, W. #, Ji, J. #, Li, X., Wang, J., Li, S., Pan, G., Fan, K. and Yang, K. * (2014) Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. Proc Natl Acad Sci U S A, 111, 5688-5693. (Faculty of 1000: http://f1000.com/prime/718339760?subscriptioncode=bf7fc944-d1bb-45e2-90a7-37602cef5dbc)

2.        Wang, W. #, Li, X. #, Li, Y., Li, S., Fan, K. and Yang, K. * (2015) A genetic biosensor for identification of transcriptional repressors of target promoters. Sci Rep, 5, 15887.

3.        Li, S. #, Wang, W. #, Li, X., Fan, K. and Yang, K. * (2015) Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. Sci Rep, 5, 15840.

4.        Li, X., Wang, J., Li, S., Ji, J., Wang, W. * and Yang, K. * (2015) ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor. Sci Rep, 5, 14831.

5.        Li, S., Wang, J., Li, X., Yin, S., Wang, W. * and Yang, K. * (2015) Genome-wide identification and evaluation of constitutive promoters in streptomycetes. Microb Cell Fact, 14, 172.

6.        Yin, S. #, Wang, W. #, Wang, X., Zhu, Y., Jia, X., Li, S., Yuan, F., Zhang, Y. and Yang, K. * (2015) Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus. Microb Cell Fact, 14, 46.

7.        Wang, W. #, Li, X. #, Wang, J., Xiang, S., Feng, X. and Yang, K. * (2013) An engineered strong promoter for streptomycetes. Appl Environ Microbiol, 79, 4484-4492.

Wang, J. #, Wang, W. #, Wang, L., Zhang, G., Fan, K., Tan, H. and Yang, K. * (2011) A novel role of 'pseudo'gamma-butyrolactone receptors in controlling gamma-butyrolactone biosynthesis in Streptomyces. Mol Microbiol, 82, 236-250.