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张延平

电话/传真:+86-10-64807351

电子邮件:zhangyp@im.ac.cn

  • 个人简介:

博士,项目研究员,从事工业生物技术研究。目前主要以代谢工程、合成生物技术、发酵调控等手段改造微生物菌种,生产生物能源和生物基化学品。


  • 教育背景:

2000.9-2006.7

清华大学化学工程系,直博,生物化工,博士学位

1996.9-2000.7

清华大学化学工程系,本科,化学工程与工艺,学士学位


  • 承担的主要科研项目:

  1. 863主题项目课题工业酵母菌种的基因组全局扰动2012.1-2015.12

  2. 973子课题异丙醇细胞工厂的性能优化2011.1-2015.8

  3. 国家自然科学基金项目氧化还原电位调控丙酮丁醇梭菌代谢的机制2012.1-2015.12

  4. 北京市自然科学基金1,2,4-丁三醇生产工程菌株的构建2012.1-2014.12


  • 5年主要论文:

  1. Yan Zhu#, Dan Li#, Shaohua Wang, Shaoming Mao, Yin Li, Yanping Zhang*. Metabolic changes of Klebsiella oxytoca in response to low oxidoreduction potential revealed by comparative proteomic profiling integrated with metabolic flux analysis. Appl. Environ. Microbiol. Accepted

  2. Hongjun Dong, Wenwen Tao, Fuyu Gong, Yin Li, Yanping Zhang*. A functional recT gene for recombineering of Clostridium. J. Biotechnol. 2014, 173(10): 65-67

  3. Yanping Zhang, Yin Li*. Engineering the antioxidative properties of lactic acid bacteria for improving its robustness. Curr. Opin. Biotechnol. 2013, 24: 142-147

  4. Shaohua Wang, Yan Zhu, Yanping Zhang*, Yin Li*. Controlling the oxidoreduction potential of the culture of Clostridium acetobutylicum leads to an earlier initiation of solventogenesis, thus increasing solvent productivity. Appl. Microbiol. Biotechnol. 2012, 93: 1021-1030

  5. Linjiang Zhu, Hongjun Dong, Yanping Zhang*, Yin Li*. Engineering the robustness of Clostridium acetobutylicum by introducing glutathione biosynthetic capability. Metab. Eng. 2011, 13: 426-434

  6. Shaohua Wang#, Yanping Zhang#, Hongjun Dong, Shaoming Mao, Yan Zhu, Runjiang Wang, Guodong Luan, Yin Li*. Formic acid triggers the "acid crash" of acetone-butanol-ethanol fermentation by Clostridium acetobutylicum. Appl. Environ. Microbiol. 2011, 77(5): 1674-1680

  7. Yanhe Zhang#, Yanping Zhang#, Yan Zhu, Shaoming Mao, Yin Li*. Proteomic analyses to reveal the protective role of glutathione in stress resistance of Lactococcus lactis. Appl. Environ. Microbiol. 2010, 76: 3177-3186